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目的分析探讨新生儿黄疸时血清总胆红素(TBIL)与总胆汁酸(TBA)的关系,以及血清TBA测定在新生儿肝胆疾病中的意义。方法回顾性分析2009年1月至2010年1月期间在我院住院治疗的76例新生儿高胆红素血症患儿的临床资料。结果新生儿高胆红素血症总胆红素TBIL和TBA浓度治疗前后比较,差异有统计学意义(P<0·01),对TBIL,和TBA浓度进行相关分析,差异无统计学意义(P>0·05)。结论新生儿高胆红素血症可造成TBA值增高,血清TBA测定在新生儿黄疸实验室诊断中具有较好的特异性和灵敏性,可为临床提供诊断和治疗依据。
Objective To analyze the relationship between serum total bilirubin (TBIL) and total bile acid (TBA) in neonatal jaundice and the significance of serum TBA in neonatal hepatobiliary diseases. Methods The clinical data of 76 neonates with hyperbilirubinaemia admitted to our hospital from January 2009 to January 2010 were retrospectively analyzed. Results The levels of total bilirubin in neonates with hyperbilirubinemia before and after treatment were significantly different (P <0.01), and the correlation between TBIL and TBA was not significant P> 0.05). Conclusions The neonatal hyperbilirubinemia can cause the increase of TBA value. The determination of serum TBA has good specificity and sensitivity in neonatal jaundice laboratory diagnosis, which can provide diagnosis and treatment basis for clinic.