L-选择素的Phe206Leu等位基因与冠心病之间的相关性

• 作 者: Hajilooi M. Tajik N. Sanati A. A. Massoud 韩瑞娟
• 机 构: Department of Immunology Tehran University of Medical Sciences,Keshavarz BLDV Tehran Iran Prof. ,
• 出 处: 世界核心医学期刊文摘(心脏病学分册)
• 发表日期: 2006年Z1期
• 关键词: 选择素 Phe206Leu 多支血管病变 基因多态性 序列特异 心病患者 血管造影 伊朗人

Background and Aims: The aim of this study was to assess the association between the L- selectin Phe206Leu polymorphism and coronary artery disease. Methods: A total of 322 patients(221 men and 101 women) with coronary artery disease in one or more vessels documented by angiography were studied; 157 subjects(85 men and 72 women) without atherosclerosis were included as controls. All subjects were genotyped for the L- selectin Phe206Leu gene polymorphism using polymerase chain reaction with sequence- specific primer(PCR- SSP). To assess disease severity, all patients were classified by numbers of coronary arteries with 50% stenosis. Results: A significantly increased frequency of the 206Leu mutant allele was observed in patients with coronary artery disease compared to the controls. The 206Leu allele frequency occurred in 42% of the patients with coronary artery disease compared to 30% of the controls(p< 0.009). No association was found between the severity of coronary artery disease and the L- selectin Phe206Leu polymorphism. Conclusion: Our findings suggest that carriage of L- selectin 206Leu mutant allele could contribute to susceptibility of Iranian individuals to contracting coronary artery disease.

Background and Aims: The aim of this study was to assess the association between the L- selectin Phe 206 Leu polymorphisms and coronary artery disease. Methods: A total of 322 patients (221 men and 101 women) with coronary artery disease in one or more vessels All subjects were genotyped for the L-selectin Phe206Leu gene polymorphism using polymerase chain reaction with sequence-specific primer (PCR-SSP). disease severity, all patients were classified by numbers of coronary arteries with 50% stenosis. Results: A significantly increased frequency of the 206Leu mutant allele was observed in patients with coronary artery disease compared to the controls. The 206 Leu allele frequency occurred in 42% of the patients with coronary artery disease compared to 30% of the controls (p <0.009). No association was found between the severity of coronary artery diseas e and the L-selectin Phe206Leu polymorphisms. Conclusion: Our findings suggest that carriage of L- selectin 206 Leu mutant allele could contribute to susceptibility of Iranian individuals to contracting coronary artery disease.