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几丁糖是一种无毒、无副作用，生物相容性良好，可在体内自然降解吸收的生物材料。利用几丁糖缓慢降解的特性，将其与阿霉素制成几丁糖阿霉素缓释药粒，并进行体外释放试验及其浸出液的体外抑制ＯＳ－１１６骨肉瘤试验。结果表明，该缓释药粒可使阿霉素呈缓慢稳定的释放，其第１，２０，４０及６０天浸出液的ＯＳ－１１６骨肉瘤的抑制率分别为５８．１１％，３６．４８％，２４．３２％及２１．６２％。认为，几丁糖与阿霉素制成的缓释药粒具有良好的缓释功能，且不影响阿霉素的活性，是化疗药物缓释的极好载体，并可应用于骨肿瘤术后的局部治疗。
Chitosan is a non-toxic, no side effects, good biocompatibility, biological materials can be naturally degraded and absorbed in the body. Using the characteristics of slow degradation of chitosan, it was made into doxorubicin with doxorubicin sustained release drug granules and in vitro release test and its leaching solution in vitro inhibition OS-116 osteosarcoma test. The results showed that the sustained-release drug particles could release doxorubicin slowly and steadily, and the inhibitory rates of OS-116 osteosarcoma on the 1st, 20th, 40th and 60th day leaching solution were 58.11%, 36.48% , 24.32% and 21.62% respectively. It is considered that sustained release tablets made of chitin and doxorubicin have a good sustained release function and do not affect the activity of doxorubicin, which is an excellent carrier for slow release of chemotherapy drugs and can be applied to postoperative Local treatment.