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目的：探讨谷胱甘肽联合果糖二磷酸钠辅助治疗慢性重型肝炎（ＣＳＨ）的疗效。方法：治疗组３０例（男性２８例，女性２例；年龄３７±ｓ８ａ），在基础治疗上加用谷胱甘肽０．６ｇ静脉推注，ｂｉｄ×４ｗｋ，果糖二磷酸钠５ｇ溶于注射用水５０ｍＬ，静脉滴注，ｑｄ×４ｗｋ。对照组３０例（男性２７例，女性３例，年龄３７±１１ａ），仅用护肝、退黄、支持、抗感染及利尿等基础治疗法。结果：治疗组ＳＢ和ＡＬＴ较治疗前明显下降（Ｐ＜０．０１），显效率４７％、总有效率７０％均优于对照组（１０％，５０％）。结论：谷胱甘肽联合果糖二磷酸钠辅助治疗ＣＳＨ安全、可靠，并具有较好疗效。
Objective: To investigate the effect of glutathione combined with sodium fructose diphosphate in the treatment of chronic severe hepatitis (CSH). Methods: The treatment group of 30 patients (28 males and 2 females; age 37 ± s8a), added to the basic treatment of intravenous injection of glutathione 0.6g, bid × 4wk, dissolved in 5g of sodium fructose diphosphate Water 50mL, intravenous infusion, qd × 4wk. The control group of 30 patients (27 males and 3 females, age 37 ± 11a), only liver, yellow, support, anti-infective and diuretic and other basic treatment. Results: SB and ALT in the treatment group were significantly lower than those before treatment (P <0.01). The effective rate was 47% and the total effective rate was 70%, which was better than that of the control group (10%, 50%). Conclusion: Glutathione combined with sodium fructose diphosphate adjuvant CSH is safe, reliable and has good curative effect.