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目的评价榄香烯乳加联合化疗治疗难治性急性非淋巴细胞白血病的疗效。方法随机将241例白血病患者分为治疗组和对照组:治疗组120例,用榄香烯乳300mg/m2/d加入5%GS 500ml中静脉滴注,持续用药14天,同时加联合化疗HAA方案:高三尖杉酯碱4mg/m2/d静滴,持续7天,阿克拉霉素20mg/m2/d静滴、qd×7天,阿糖胞苷100~200mg/m2/d,第1~7天;对照组121例,单用HAA化疗,方案用量用法同治疗组。结果治疗组120例中有85例CR,有12例PR,NR23例,CR率70.8%(85/120),总有效率80.8%(97/16)。对照组121例中CR53例,PR11例,NR57例,CR率为43.8%(53/121),总有效率52.9%(64/121)。差异有显著性(P<0.05)。结论榄香烯乳对难治性急性非淋巴细胞白血病(ANLL)有肯定疗效,比单用联合化疗效果好,且不良反应少,无血象和骨髓抑制。
Objective To evaluate the efficacy of elemene combined with chemotherapy in the treatment of refractory acute non-lymphocytic leukemia. Methods 241 patients with leukemia were randomly divided into treatment group and control group. The treatment group consisted of 120 patients. The patients were treated with elemene 300mg / m2 / d by adding 5% GS 500ml intravenous infusion for 14 days. Combined with HAA Program: homoharringtonine 4mg / m2 / d intravenous infusion for 7 days, aclacinomycin 20mg / m2 / d intravenous infusion, qd × 7 days, cytarabine 100 ~ 200mg / m2 / d, the first ~ 7 days; control group of 121 cases, HAA alone chemotherapy, the amount of the same usage of the treatment group. Results Among the 120 patients in the treatment group, 85 were CR, 12 were PR and NR, and the CR rate was 70.8% (85/120). The total effective rate was 80.8% (97/16). The control group of 121 cases of CR53 cases, PR11 cases, NR57 cases, CR rate was 43.8% (53/121), the total effective rate was 52.9% (64/121). The difference was significant (P <0.05). Conclusion Elemene has definite curative effect on refractory acute non-lymphocytic leukemia (ANLL), which is better than combined chemotherapy alone with less adverse reactions, no blood and bone marrow suppression.