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目的探讨鼻腔鼻窦淋巴瘤不同治疗模式的近期疗效及对远期生存质量的影响。方法针对不同分期鼻腔鼻窦淋巴瘤患者分别采用手术加同步放化疗(A)、同步放化疗(B)、手术加放疗(C)的治疗模式。结果全组患者5年总生存率66.7%,无病生存率(DFS)36.7%,A组完全缓解率(complete response rate,CR)57.1%比B组44.4%或C组42.9%均差异有统计学意义。B组44.4%比C组42.9%差异无统计学意义。5年总生存率(overall survival,OS)A组71.4%、B组66.7%﹥C组57.1%,差异有统计学意义。结论同步放化疗相对单纯放疗或化疗而言,提高了远期生存。早期较局限的鼻腔鼻窦淋巴瘤先手术再同步放化疗的治疗模式可以提高无病生存率及完全缓解率。
Objective To investigate the short-term effect of different treatment modalities of nasal sinus and lymphoma on long-term quality of life. Methods Patients with different stages of nasal sinonasal lymphoma were treated with concurrent chemoradiotherapy (A), concurrent chemoradiotherapy (B), surgery plus radiotherapy (C) treatment. Results The overall 5-year overall survival rate was 66.7%, the disease-free survival rate (DFS) was 36.7%. The complete response rate (CR) in group A was 57.1%, which was significantly lower than that in group B 44.4% or group C 42.9% Significance of learning. There was no significant difference in 44.4% of the patients in group B compared with 42.9% in group C. The 5-year overall survival (OS) was 71.4% in group A, 66.7% in group B and 57.1% in group C, the difference was statistically significant. Conclusions Simultaneous chemoradiation improves long-term survival compared to radiotherapy or chemotherapy alone. Early limited nasal sinus lymphoma surgery resynchronization chemoradiation treatment model can improve disease-free survival and complete remission rate.