Lipophilicity determination of N-( benzothiazol-2-yl )-α-amino alkyl phosphonic diesters by RP-HPLC

• 作 者: 张玲 李在国 黄润秋 王琴孙
• 机 构: State Key Laboratory of Elemento-Organic Chemistry,Nankai University, Tianjin 300071, China,State Ke
• 出 处: Chinese Journal of Chemistry
• 发表日期: 2000年06期
• 关键词: alkyl retention methanol mixtures listed reversed packed decreasing disadvantage

Using methanol-water mixtures as the mobile phase,the chro-matographic retention parameters k’ and Rf were determined by reversed-phase high-performance liquid chromatography(RP-HPLC)and reversed-phase high-performance thin-layer chromatography(RP-HPTLC)for N-(benzothiazol-2-yl)-o) amino alkyl phosphonic diesters and the correlation with lipophilicity parameter(ClogP)was established.Logkw values obtained from RP-HPLC and R values obtained from RP-HPTLC can be used to evaluate the lipophilicity of this kind of compounds.Chromatographic method is a good alternative for lipophilicity measurement.

Using methanol-water mixtures as the mobile phase, the chro-matographic retention parameters k ’and Rf were determined by reversed-phase high-performance liquid chromatography (RP- HPTLC) for N- (benzothiazol-2-yl) -o) amino alkyl phosphonic diesters and the correlation with lipophilicity parameter (ClogP) was established. Logkw values ​​obtained from RP-HPLC and R values ​​obtained from RP-HPTLC can be used to evaluate the lipophilicity of this kind of compounds. Chromatographic method is a good alternative for lipophilicity measurement.