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目的探讨尿微量蛋白和尿酶在过敏性紫癜(HSP)患儿早期肾损伤中的作用和临床意义。方法2004-10—2005-10在内蒙古医学院第三附属医院儿科和皮肤科住院的HSP患儿共43例,采用免疫散射比浊法和酶法测定患儿尿微量白蛋白(MA)、转铁蛋白(TRF)、β2微-球蛋白(β2-MG)和尿酶N-乙酰-β-D氨-基-葡萄糖胺酶(NAG)的水平,同时检测尿常规和血尿素氮(BUN)、肌酐(Scr)水平。结果HSP患儿尿4项指标明显高于对照组,4项指标异常率79.07%(34/43),尿常规异常率13.95%(6/43);37例尿常规正常者4项指标异常率达70.57%(28/37),且4项指标较单项指标异常发生率高。结论尿4项指标联合检测是诊断HSP早期肾损伤的灵敏指标,可作为临床早期诊断、早期干预治疗以降低肾损伤程度的可靠依据。
Objective To investigate the role of urinary microalbumin and urease in early renal injury in children with Henoch-Schonlein purpura (HSP) and its clinical significance. Methods A total of 43 children with HSP who were hospitalized in pediatrics and dermatology department of the Third Affiliated Hospital of Inner Mongolia Medical University from October 2004 to June 2005 were enrolled in this study. Urine microalbumin (MA) (TRF), β2 microglobulin (β2-MG) and urinary N-acetyl-β-Damino-glucosaminidase (NAG) were measured. Urinary routine tests and blood urea nitrogen (BUN) , Creatinine (Scr) levels. Results Four indexes of urinary HSP in children with HSP were significantly higher than those in the control group (79.07%, 34/43) and abnormal urine (13.95%, 6/43) Up to 70.57% (28/37), and the four indicators were higher than the single indicators of abnormal incidence. Conclusions The combined detection of 4 indicators of urine is a sensitive index for diagnosis of early kidney injury in HSP and can be used as a reliable basis for early clinical diagnosis and early intervention to reduce the degree of renal injury.