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多氧取代环己烯是一类比较独特的天然产物,分子中多具有四个手性中心,立体化学多变,尽管用化学衍生物方法确定了部分化合物的绝对构型,但对已报道的化合物中仍有大部分未能确定其构型.在阐明分子相对构型的基础上,应用激子手性方法确定此类化合物的绝对构型,并利用Alchemy程序进行了分子动力学计算,对此类化合物的圆二色性规律进行了总结.
Polyoxo-substituted cyclohexenes are a kind of unique natural products. They have four more chiral centers in their molecules and have many stereochemical changes. Although the absolute configuration of some compounds has been confirmed by chemical derivatives, Most of the compounds still have not been able to determine their configuration. Based on the elucidation of the relative configuration of the molecules, the absolute configuration of these compounds was determined by excitochiral method and the molecular dynamics calculations were performed by Alchemy program. The circular dichroism of these compounds is summarized.