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重型颅脑外伤后,患者T淋巴细胞及树突状细胞介导的细胞免疫和B淋巴细胞介导的体液免疫均明显降低,导致机体免疫力下降,易发生感染等并发症;同时各种细胞因子的不适当激活又可诱发免疫紊乱,导致全身炎性反应综合征的发生;脑抗原的免疫攻击可使颅脑外伤患者的病情恶化。近年来,颅脑外伤后的亚低温治疗、谷氨酰胺和精氨酸为组方的肠内免疫营养支持、中药黄芪、免疫抑制剂环孢素等的免疫调理成了颅脑外伤患者治疗的热点。
After severe craniocerebral trauma, the T cell and dendritic cell-mediated cellular immunity and B lymphocyte-mediated humoral immunity were significantly reduced, leading to the decline of immunity, prone to complications such as infection; the same time, a variety of cells Inappropriate activation of factors in turn can induce immune disorders, leading to the occurrence of systemic inflammatory response syndrome; immune challenge of brain antigen can make patients with brain trauma worsened. In recent years, mild hypothermia after traumatic brain injury, glutamine and arginine for the group of intestinal immune and nutritional support, astragalus traditional Chinese medicine, immunosuppressive agents such as cyclosporine immunosuppression became traumatic brain injury patients treated Hot spots.