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用L929细胞生物学活性法测定了10例新生儿败血症合并新生儿硬肿症患者的血浆肿瘤坏死因子-α(TNFα)水平,其值为788.0±685.61u/ml,显著高于新生儿败血症患者、单纯寒冷因素所致新生儿硬肿症患者及正常新生儿,死亡组的TNFα水平又较存活组显著增高。提示TNFα水平的增高与严重败血症所致新生儿硬肿症的发病和预后有关。
The plasma level of tumor necrosis factor-α (TNFα) in 10 neonates with sepsis and neonatal sclera was measured by L929 cell biological activity assay, which was 788.0 ± 685.61u / ml, which was significantly higher than that in neonates with sepsis , Pure cold caused by neonatal scleredema and normal newborns, TNFα levels in the death group was significantly higher than the survival group. Tip TNFα levels increased with severe sepsis-induced neonatal sclera disease incidence and prognosis.