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目的 :利用动物 (狗 )探讨丝裂霉素对胰腺组织的动态穿透行为。方法 :6只杂种狗 ,胰腺导管引流术后静脉给予丝裂霉素 ,动态采集并测定 0～ 2 4 0min内血浆及胰液中药物浓度 ,利用PCNONLIN程序进行其动力学模型和参数分析及统计学判定。结果 :丝裂霉素在血浆及胰液中均符合二室开放模型 ;胰液中药物tmax和cmax分别为 ( 0 .3 6± 0 .1 6)h和 ( 65 .6± 75 .8) μg·L-1;丝裂霉素血浆及胰液t1/ 2 β分别为 ( 1 .1 7± 0 .96)h和 ( 0 .71± 0 .66)h ,AUC0～∞ 分别为 ( 1 0 7.9± 4 3 .9) μg·h·L-1和 ( 3 3 .5±2 8.8) μg·h·L-1。结论 :丝裂霉素静注后很快进入胰液 ,但其药物水平始终低于血浆 ,且胰液中药物消除略快于血浆 (P <0 .0 1 ) ;其胰液通透指数 (PI)平均为 0 .3 1± 0 .1 9。
Objective: To investigate the dynamic penetration of mitomycin into pancreatic tissue by using animal (dog). Methods: Six mongrel dogs were given intravenous MMC after draining the pancreatic duct. The concentrations of plasma and pancreatic juice in 0 ~ 240min were dynamically collected and determined by PCNONLIN program. The kinetic models and parameters were analyzed and statistically analyzed determination. RESULTS: Mitomycin had a two-compartment open model in both plasma and pancreatic juice. The tmax and cmax in pancreatic juice were (0.36 ± 0.16) h and (65.6 ± 75.8) μg · L-1; t1 / 2 β of mitomycin in plasma and pancreatic juice were (1.17 ± 0.96) h and (0.71 ± 0.66) h, AUC0 ~ ∞ were 4 3 .9) μg · h · L-1 and (3 3 .5 ± 2 8.8) μg · h · L-1. CONCLUSION: Mitomycin rapidly enters the pancreatic juice after intravenous injection, but its drug level is always lower than that of plasma, and the drug in pancreatic juice is eliminated slightly faster than that of plasma (P <0.01). The average permeability index of pancreatic juice (PI) Is 0 .3 1 ± 0 .1 9.