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The efficacy of platelet-rich plasma (PRP) to promote tissue regeneration has been largely confirmed in several clinical settings,such as in human maxillo-facial (Froum et al.,2002),heart (Vu et al.,2015) and orthopaedic surgery (Zhang and Wang,2010).Up to date,few studies are available regarding the topical use of platelet-rich plasma in models of peripheral nerve injury or central nervous system pathology and the results contrasting.