论文部分内容阅读
关于非胰岛素依赖型糖尿病(NIDDM)的遗传问题,近年来已认识到它具有家族倾向,同卵孪生子几乎同时发病的一致性为 NIDDM 的遗传基础提供了强有力的依据。以前提出的发病危险因素仍应考虑,但离开家族分析是不符合基本的孟德尔规律。遗传缺陷能影响葡萄糖代谢的任何一个调节阶段,遗传因素本身或与环境因素一起均可导致NIDDM。已知至少有60种不同的遗传性疾病可出现葡萄糖耐量异常或发生临床糖尿病,提示在不同
With regard to the genetic problem of non-insulin-dependent diabetes mellitus (NIDDM), it has been recognized in recent years that it has a familial propensity and that the almost simultaneous coincidence of identical twins provides a strong basis for the genetic basis of NIDDM. The previously proposed risk factors for morbidity should still be considered, but leaving the family analysis is inconsistent with the basic Mendelian law. Genetic defects can affect any one of the regulatory stages of glucose metabolism, genetic factors alone or together with environmental factors can lead to NIDDM. It is known that at least 60 different hereditary diseases can develop impaired glucose tolerance or develop clinical diabetes, suggesting that in different