2型糖尿病患者血浆促酰化蛋白与血脂的相关性探讨

• 作 者: 卢慧玲 王宏伟 林汉华 张木勋
• 机 构: 华中科技大学同济医学院附属同济医院儿科,华中科技大学同济医学院附属同济医院儿科,华中科技大学同济医学院附属同济医院儿科,华中科技大学同济医学院附属同济医院内分泌科 武汉,430030,武汉,43003
• 出 处: 中国实用内科杂志
• 发表日期: 2004年03期
• 关键词: 促酰化蛋白 糖尿病 血脂

目的　测定 2型糖尿病患者血浆促酰化蛋白 (ASP)浓度 ,并探讨血浆ASP质量浓度与血脂各指标的相关性。方法　采用ELISA方法检测血浆ASP浓度 ,用免疫比浊法检测血脂指标 ,并分析ASP与血脂的相关性。结果　⑴糖尿病组ASP浓度明显高于正常对照组 ,差异有显著性 ( P〈0 0 1)。⑵糖尿病组血浆TCh、TG、HDL c、LDL c、ApoA、ApoB与正常对照组相比 ,均存在差异有显著性 (P〈0 0 5 )。⑶ASP与BMI、TCh、TG、LDL、ApoB10 0呈显著正相关 (分别为r =0 32 ,P〈0 0 1;r =0 35 ,P〈0 0 1;r =0 2 1,P〈0 0 5 ;r =0 2 9,P〈0 0 1;r=0 32 ,P〈0 0 1)。结论　血浆ASP的异常与 2型糖尿病血脂紊乱的发生密切相关。

Objective To determine the level of plasma acyl-stimulating protein (ASP) in patients with type 2 diabetes mellitus (T2DM) and to explore the correlation between plasma ASP concentration and serum lipid levels. Methods Plasma ASP concentration was measured by ELISA. Serum lipids were measured by immunoturbidimetry. The correlation between serum ASP was analyzed. Results (1) ASP concentration in diabetic group was significantly higher than that in normal control group, the difference was significant (P <0.01). The plasma TCh, TG, HDLc, LDLc, ApoA and ApoB in diabetic group were significantly different from those in normal control group (P <0.05). There was a significant positive correlation between ASA and BMI, TCh, TG, LDL and ApoB10 0 (r = 0 32, P 0 01; r 0 35, P 0 01; 0 5; r = 0 2 9, P <0 0 1; r = 0 32, P <0 0 1). Conclusion The abnormality of plasma ASP is closely related to the occurrence of dyslipidemia in type 2 diabetic patients.