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目的：：研究口腔鳞癌组织（OSCC）中树突状细胞(DCs)的浸润密度的临床意义。方法：采用免疫组织化学染色S-P法检测S-100表达标记DCs，根据临床情况进行统计学分析。结果：OSCC中DCs浸润密度低于正常对照组（P=0.016），无转移组OSCC组织内DCs明显高于转移组，（P=0.010）。DCs浸润密度Ⅰ>Ⅱ>Ⅲ级，（P=0.030）。结论：DCs浸润密度与OSCC分化程度及转移关系密切， DCs在抑制肿瘤肿瘤发展、转移中起到一定的作用。“,”Objective To investigate dendritic cells(DCs) infiltration to assess their significances in the metastasis and prognosis in the oral squamous-cell carcinoma(OSCC).MethodsImmunohistochemistry S-P method was adopted to identify DCs infiltration, S-100 protein was used to mark DCs.Results DCs infiltration in normal oral mucosa were significantly higher in OSCC ( P = 0.016). The density of DCs in the group with lymph nodes metastasis was clearly lower than in the group with no lymph nodes metastasis in OSCC (P=0.010). The density of DCs were obviously decreased along differentiation of tumor,Ⅰ>Ⅱ>Ⅲ(P=0.030).Conclusion DCs infiltration was closely associated with tumor differentiation and lymph nodes metastasis, might inhibit the tumor progression and lymph nodes metastasis in OSCC.