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胰高血糖素是脑——肠肽的一种,其化学本质早已明确,在脑内的生理功能,特别是对脑的高级功能的研究未见报道。本实验采用脑室给药的方法,以观察胰高血糖素对小鼠记忆的影响。 材料和方法 小白鼠(非近亲交系)60只,体重18—22g。雌雄兼用,随机分组,每10只一组。实验前以组为单位将小鼠放入木制迷宫中(长1OOcm,宽80cm,高18cm,从A到B处设有八个迷路胡同),让它们在迷宫中连续活动四小时。凡在第一小时内不能到达取食处(B)者即予淘汰。尔后经
Glucagon is a kind of brain-gut peptide. Its chemical nature has already been clarified. The physiological function in brain, especially the study of advanced brain function, has not been reported. In this experiment, intraventricular administration was used to observe the effect of glucagon on the memory of mice. Materials and Methods 60 mice (non-inbreeding) 60 mice weighing 18-22 g. For both male and female, randomly divided into groups of 10 each. Before the experiment, the mice were placed in a wooden maze (100 cm in length, 80 cm in width, 18 cm in height, and eight stray alleys from A to B) in a group unit, and they were allowed to continuously move in the maze for four hours. Those who cannot reach the feeding place (B) within the first hour will be eliminated. Afterwards