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目的分析慢性肝病患者发生小肠细菌过度生长(SIBO)的情况及其与轻微肝性脑病(MHE)之间的关系。方法收集慢性肝病患者41例作为观察组,并选择同期健康者41例作为对照组,对比分析两组SIBO情况以及MHE情况。结果观察组检查出15例(36.6%)SIBO,显著高于对照组的2例(4.9%);观察组有16例(39.0%)MHE,其中11例(68.8%)SIBO合并MHE,5例(31.2%)MHE无SIBO,两者比较差异具有统计学意义(P<0.05);有SIBO者的血氨值显著高于无SIBO者(P<0.05);慢性肝病患者的SIBO与MHE之间存在显著相关性(P<0.05)。结论慢性肝病患者发生MHE与SIBO有关,而血氨水平对于慢性肝病SIBO合并MHE者可能有促进作用。
Objective To analyze the situation of intestinal bacterial overgrowth (SIBO) in patients with chronic liver disease and its relationship with mild hepatic encephalopathy (MHE). Methods Forty-one patients with chronic liver disease were selected as the observation group and 41 healthy controls were selected as the control group. The SIBO status and MHE were compared between the two groups. Results In the observation group, SIBO was found in 15 cases (36.6%), which was significantly higher than that in control group (4.9%). Sixteen patients (39.0%) had MHE in observation group, 11 cases (68.8% (31.2%) MHE without SIBO, the difference between the two was statistically significant (P <0.05); SIBO blood ammonia value was significantly higher than those without SIBO (P <0.05); patients with chronic liver disease SIBO and MHE There was a significant correlation (P <0.05). Conclusions The occurrence of MHE in patients with chronic liver disease is related to SIBO, and the level of serum ammonia may promote SIBO with MHE in chronic liver disease.