论文部分内容阅读
目的:比较在乳腺癌前哨淋巴结活检术(sentinel lymph node biopsy, SLNB)中使用亚甲蓝单示踪剂和亚甲蓝联合核素双示踪剂的效果。方法:2017年11月至2019年10月，就诊于山东省肿瘤医院的乳腺癌患者92例，SLNB均使用亚甲兰联合核素双示踪剂；就诊于济宁市第一人民医院的患者92例，SLNB均使用亚甲兰单示踪剂。比较两组前哨淋巴结(SLN)的检出数量、检出率、准确率、灵敏度、假阴性率，分析患者的年龄、月经情况、肿瘤部位、肿瘤长径、临床分期、病理类型、雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体2(HER-2)、分子分型、动态增强磁共振成像(DCE-MRI)对SLN检出率的影响。结果:单示踪剂组的检出数量、检出率、准确率、灵敏度、假阴性率分别为(3.20±1.10)枚、90.22%、93.48%、95.24%和4.76%，双示踪剂组分别为(3.37±1.02)枚、92.39%、95.65%、95.65%和4.35%，两组差异均无统计学意义(均n P>0.05)。按照患者的年龄、月经情况、病理类型、临床分期、肿瘤部位、ER表达、PR表达、HER-2表达、分子分型分层后，单示踪剂组和双示踪剂组的SLN检出率差异均无统计学意义(均n P>0.05)。但按照肿瘤长径和DCE-MRI检查分层后，在肿瘤长径为2～5 cm或未行DCE-MRI检查的情况下，单示踪剂组的SLN检出率明显低于双示踪剂组(均n P0.05). In different age, menstrual condition, tumor location, clinical stage, pathological type, ER, PR, HER-2 expression and molecular typing, the detection rate of single tracer group and double tracer group had no significant difference (alln P>0.05). However, in the tumor size of 2-5 cm and without DCE-MRI examination, the detection rate of single tracer group was significantly lower than that of double tracer group.n Conclusion:The effect of blue dye single tracer in detecting SLN of breast cancer is equivalent to that of double tracer method, which is worthy of promotion and application in primary hospitals.