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1987年 Morris 等报道一例摄食幽门螺旋菌(HP)的志愿者,其症状虽仅持续10天,但感染与胃炎的组织学改变持续67天,经碱式水杨酸铋治疗1个月,一周后(第103天)作活检见 HP被清除,组织学胃炎几乎完全消失。作者对此例又作了54个月的长期随访并复查胃活检以检测有否复发。在第359天,即胃炎明显消散后约9个月,活检示快速尿素酶试验(+)及有 HP,组织学有活动性慢性胃炎,中度混合性炎细胞浸润,有中性、淋巴、浆细胞,有时见嗜酸性细胞浸润至粘膜固有层。中性粒细胞点状浸润到腺体及隐窝上皮。先用氟哌酸无效,后用18天羟氨苄青
In 1987, Morris et al. Reported a case of volunteers who ingested Helicobacter pylori (HP) whose symptoms persisted for only 10 days. However, the histological changes of infection and gastritis persisted for 67 days and were treated with bismuth sub salicylate for 1 month and one week After the (day 103) biopsy to see HP was cleared, histological gastritis almost completely disappeared. The authors made a further 54-month follow-up of this case and reviewed gastric biopsy to detect any recurrence. On day 359, about 9 months after the gastritis had dissipated, the biopsy showed rapid urease test (+) with HP, histologically active chronic gastritis, moderate mixed inflammatory cell infiltration with neutral, lymphatic, Plasma cells, sometimes see eosinophil infiltration into the lamina propria. Neutrophils dotted infiltration of glands and crypt epithelium. First with norfloxacin invalid, after 18 days with amoxicillin