PROTECTIVE ACTION OF BUDIPINE AGAINST MPTP NEUROTOXICITY

• 作 者: 盛锦根 徐德隆 余慧贞 徐修蓉 唐琴梅
• 机 构: DepartmentofNeurology,RuijinHospital,SSMU,Shanghai,ShanghaiInstituteofMateriaMedica,AcademiaSinica,S
• 出 处: 上海交通大学学报：医学英文版
• 发表日期: 1990年2期
• 关键词: budipine MPTP DOPAMINE budipine MPTP dopamine

Mice treated with large dose of MPTP showed a reduction in the levels of DA, 5-HT and their metabolites in the striatum. The average levels as compared with the control were reduced by 94% for DA (P【0.001), 61% for DOPAC (P【0.05), 65% for HVA (P【0.01). 5-