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目的探讨肿瘤标志物CA242与细胞因子TGF-β联合检测对诊断胰腺癌的临床价值。方法选择天津医科大学总医院2004年12月至2005年9月胰腺癌患者30例,采用ELISA方法检测血清CA242水平,其中20例同时检测TGF-β水平。对照组为健康志愿者20名。结果30例胰腺癌患者中CA242高于正常值者20例,平均值(312±5)kU/L;对照组中2例高于正常值,平均值(56±2)kU/L,P<0.01。20例TGF-β检测结果高于正常值者16例,平均值(245.31±25.12)ng/L;对照组中1例稍高于正常值(112.31ng/L,P<0.01)。CA242检测胰腺癌的敏感性为66.7%,低于TGF-β的敏感性(80.0%),P<0.05;两者检测胰腺癌的特异性分别为90.0%和95.0%,P>0.05。结论CA242、TGF-β诊断胰腺癌的特异性均较高,TGF-β的敏感性高于CA242;两者联合检测可提高胰腺癌的诊断率。
Objective To investigate the clinical value of combined detection of tumor marker CA242 and cytokine TGF-β in the diagnosis of pancreatic cancer. Methods Thirty patients with pancreatic cancer from December 2004 to September 2005 were selected from Tianjin Medical University General Hospital. The level of serum CA242 was detected by ELISA, and the levels of TGF-β were also detected in 20 of them. Control group of 20 healthy volunteers. Results Among 30 patients with pancreatic cancer, CA242 was higher than the normal value in 20 patients with an average of (312 ± 5) kU / L; in the control group, 2 patients were higher than the normal value (56 ± 2) kU / L, P < 0.01.20 cases of TGF-β test results were higher than the normal 16 cases, mean (245.31 ± 25.12) ng / L; control group, a slightly higher than the normal value (112.31ng / L, P <0.01). The sensitivity of CA242 for detecting pancreatic cancer was 66.7%, lower than that of TGF-β (80.0%), P <0.05. The specificity of CA242 for detecting pancreatic cancer was 90.0% and 95.0%, respectively, P> 0.05. Conclusion The specificity of CA242 and TGF-β in the diagnosis of pancreatic cancer is high, and the sensitivity of TGF-β is higher than that in CA242. The combined detection of CA242 and TGF-β can improve the diagnosis rate of pancreatic cancer.