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Framingham地区年龄在29～62岁的2,873名妇女,从1948年起给予全面的心血管检查,以后每2年常规复查一次,生存者至今已接受第15次检查。分析资料取自最初的13次检查,此时最年轻者为54岁,实际上均已绝经。在统计上分绝经前、绝经期与绝经后三期。冠心病的诊断标准为:有心绞痛病史;冠状动脉机能不全的病史与心电图表现;指示有心肌梗塞的病史、心电图表现、酶谱变化与尸检发现因冠心病死亡。结果:Framingham地区妇女约3/4为自然绝经,1/4为手术绝经,其中半数作双侧卵巢切除术。在40～44岁年龄组,手术绝经的冠心病发病率与绝经前妇女相比为18:1(P<0.001),45～54岁年龄组则为2.7:1(P<0.01)。在45～54岁年龄组,自然绝经与绝经前妇女的冠心病发病率之比亦为2.7:1,两种绝经方式妇女冠心病中心肌梗塞所占的
In Framingham, 2,873 women aged 29-62 years received a complete cardiovascular examination from 1948 onwards, and routinely reviewed every 2 years thereafter. Survivors have so far received the 15th examination. Analytical data were taken from the initial 13 exams, the youngest being 54 and virtually all menopause. Separation of premenstrual statistics, menopause and postmenopausal three. The diagnostic criteria for coronary heart disease were: a history of angina; a history of coronary insufficiency and electrocardiogram; a history of myocardial infarction, electrocardiographic findings, zymogram changes and autopsy findings of death from coronary heart disease. RESULTS: About three-quarters of women in Framingham were naturally menopause, one-fourth were surgical menopause and half were ovariectomized. In 40-44 age group, the incidence of coronary heart disease was 18: 1 (P <0.001) in menopausal women and 2.7: 1 in 45-54 years old group (P <0.01). In the 45- to 54-year-old age group, the incidence of coronary heart disease in premenopausal and premenopausal women was also 2.7: 1, and the percentage of MI in both menopausal women with coronary heart disease