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内皮抑素是一种抑制肿瘤新生血管形成的因子,不仅能有效抑制肿瘤血管生成,还能抑制肿瘤的浸润转移,显示出较好的抗肿瘤活性和低毒性,是目前作用最强、实验效果最好的肿瘤血管生成抑制剂。但内皮抑素是一种蛋白多肽类药物,在体内容易被广泛分布的蛋白水解酶降解,同时容易被肾脏清除,导致其半衰期过短,难以在体内长时间保留,缺乏稳定性,从而无法充分发挥抗血管作用。目前有多项研究致力于延长内皮抑素的半衰期,
Endostatin is a factor that inhibits tumor angiogenesis, not only can effectively inhibit tumor angiogenesis, but also inhibit tumor invasion and metastasis, showing good anti-tumor activity and low toxicity, is currently the strongest, experimental results The best tumor angiogenesis inhibitor. Endostatin, however, is a protein peptide drug that is easily degraded by widely distributed proteases in the body and easily cleared by the kidneys, resulting in a too short half-life, poor retention in the body, and lack of stability, resulting in inadequate Play anti-vascular effects. There are a number of studies devoted to extending the half-life of endostatin,