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目的 :研究温度对聚桂醇泡沫稳定性的影响。方法 :实验分为2组,预处理组—将盛有聚桂醇注射液的注射器及盛有空气的注射器通过三通管连接后,置于不同温度中(5、15、25、35、45、55和65℃),预处理10 min后,根据Tessari法制备聚桂醇泡沫。记录泡沫在室温(T=25℃)条件下的半衰期;后处理组—先在室温条件下制备聚桂醇泡沫,然后记录泡沫在不同温度下(5、15、25、35、45、55和65℃)的半衰期。利用SPSS 19.0软件包进行统计学分析。结果:在预处理组和后处理组,温度与聚桂醇泡沫的半衰期均存在负相关性(预处理组:r=-0.984,P<0.05;后处理组:r=-0.969,P<0.05)。T=25℃时,预处理组与后处理组之间的泡沫半衰期无显著差异(P=0.428>0.05);T>25℃时,预处理组半衰期高于后处理组;T<25℃时,预处理组半衰期低于后处理组,差异均有显著性(P<0.05)。结论:温度是影响聚桂醇泡沫稳定性的一个重要因素,泡沫制备前的温度与制备后的温度对泡沫稳定性的影响存在差异。
Objective: To study the effect of temperature on the stability of lauromacrogol foam. Methods: The experiment was divided into two groups. The pretreatment group was placed in different temperature (5, 15, 25, 35, 45) with the syringes filled with lauromacyl alcohol injection and the syringe filled with air. , 55 and 65 ° C). After pretreatment for 10 min, lauromacrogol foam was prepared according to the Tessari method. The half-life of the foam was recorded at room temperature (T = 25 ° C); the post-treatment group - the lauromacrogol foam was prepared first at room temperature and then the foam was recorded at different temperatures (5, 15, 25, 35, 45, 65 ° C) half-life. SPSS 19.0 software package for statistical analysis. Results: There was a negative correlation between temperature and half-life of lauryl alcohol foam in the pretreatment group and the posttreatment group (pretreatment group: r = -0.984, P <0.05; posttreatment group: r = -0.969, P <0.05 ). At T = 25 ℃, there was no significant difference in the half-life of the foam between the pretreatment group and the aftertreatment group (P = 0.428> 0.05). When the T> 25 ℃, the half- , The half-life of the pretreatment group was lower than the post-treatment group, the difference was significant (P <0.05). CONCLUSION: Temperature is an important factor affecting the stability of lauromacrogol foam. The effect of temperature before foaming and the temperature after preparation on the foam stability are different.