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目的:观察两种途径注射纳洛酮对脑梗死病人脑脊液β-内啡肽的影响。方法:用盐酸纳洛酮治疗84例急性脑梗死病人,其中44例通过动脉留置管注射,40例从静脉注射,测定治疗前和治疗后脑脊液中β-内啡肽含量。结果:颈动脉用药组,β-内啡肽含量治疗后明显下降(P<0.05),神经功能恢复程度亦优于静脉用药组。
Objective: To observe the effects of naloxone injection on β-endorphin in cerebrospinal fluid of patients with cerebral infarction by two ways. Methods: Eighty-four patients with acute cerebral infarction were treated with naloxone hydrochloride. Forty-four patients were injected with arterial catheter and 40 cases were injected intravenously. The contents of β-endorphin in cerebrospinal fluid before and after treatment were determined. Results: The content of β-endorphin in the carotid artery administration group decreased significantly after treatment (P <0.05), and the degree of neurological function recovery was superior to that of the intravenous administration group.