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目的比较人附睾分泌蛋白4(HE4)和糖类抗原125(CA125)在预测满意肿瘤细胞减灭术中的作用。方法 99例以“盆腔肿物”住院的患者,根据术后病理结果分为卵巢恶性肿瘤组(33例)和卵巢良性肿物组(66例),测定血清HE4、CA125的浓度。结果 HE4在浆液性癌组、晚期组、不满意肿瘤细胞减灭术组浓度530.15、408.7、549.2 pmol/L高于非浆液性癌组、早期组、满意组(P<0.01),在卵巢浆液性癌(OSC)高级别组与OSC低级别组间比较差异无统计学意义(P>0.05)。CA125在各对应分组间比较差异均无统计学意义(P>0.05)。结论 HE4诊断浆液性卵巢癌的敏感度和特异度均较高;术前血清HE4浓度高提示肿瘤为晚期;术前血清HE4浓度高提示不满意的肿瘤细胞减灭。
Objective To compare the role of human epididymal secreted protein 4 (HE4) and carbohydrate antigen 125 (CA125) in predicting satisfactory cytoreductive surgery. Methods Ninety-nine patients with pelvic masses were divided into three groups: ovarian malignant tumor group (33 cases) and benign ovarian tumor group (66 case) according to postoperative pathological results. Serum levels of HE4 and CA125 were measured. Results The levels of HE4 in serous carcinoma group, advanced group and unsatisfied tumor cytoreductive group were higher than those in non-serous carcinoma group, early group and satisfied group (530.15,408.7,549.2 pmol / L, P <0.01) There were no significant differences between OSC high-grade group and OSC low-grade group (P> 0.05). There was no significant difference in CA125 between the corresponding subgroups (P> 0.05). Conclusions The sensitivity and specificity of HE4 in the diagnosis of serous ovarian cancer are high. Preoperative high concentration of HE4 indicates that the tumor is advanced. Preoperative high concentration of HE4 suggests dissatisfied tumor cells.