论文部分内容阅读
研究了β－胡萝卜素（β－ｃａｒｏｔｅｎｅ）在ＳｗｉｓｓＮＩＨ／３Ｔ３细胞中的代谢情况及其对促癌剂ＴＰＡ（１２－ｏ－ｔｅｔｒａｄｅｃａｎｏｙｌ－１３－ｐｈｏｒｂｏｌ－ａｃｅｔａｔｅ）抑制ＮＩＨ／３Ｔ３细胞间隙连接通讯（ＧＪＩＣ）的影响。结果显示：β－胡萝卜素在ＮＩＨ／３Ｔ３细胞中不能转化为视黄醇，对ＮＩＨ／３Ｔ３细胞ＧＪＩＣ功能有诱导作用，同时对ＴＰＡ抑制ＮＩＨ／３Ｔ３细胞ＧＪＩＣ功能有不同程度的拮抗作用。提示β－胡萝卜素的抗癌作用可能与细胞ＧＪＩＣ功能变化有关。
The metabolism of β-carotene in Swiss NIH/3T3 cells and its inhibition of NIH/3T3 cell gap junctional communication by TPA (12-o-tetradecanoyl-13-phorbol-acetate) was studied. )Impact. The results showed that β-carotene could not be converted into retinol in NIH/3T3 cells, which could induce the GJIC function of NIH/3T3 cells, and it also had different degrees of antagonism on the inhibition of GJIC function of NIH/3T3 cells by TPA. It is suggested that the anticancer effect of β-carotene may be related to the change of cellular GJIC function.