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肿瘤是细胞在不受抑制地增殖时而形成 ,恶性肿瘤能入侵周围的细胞 ,尤其是具攻击性的恶性肿瘤细胞 ,先穿透一层基层膜 (Basem ent mem brane)后转移和扩散到其他的器官里去。基层膜是特殊分化的细胞外基质 ,正常细胞无法穿透这层基层膜。L am inin是一种大分子糖蛋白 .它们广泛地分布于细胞外基质中。通过细胞表面受体而具有与细胞之间沟通的能力。它们是入侵癌细胞主要的附着基体。恶性癌细胞直接粘附于 lam inin与癌细胞潜在的转移性直接相关。研究发现 lam inin呈高亲和力粘附于癌细胞表面并可呈饱和状态 ,暗示有 laminin的受体存在。后来发现有一种 6 7k D laminin受体 (6 7L R)和 laminin有高亲和力。众多的研究发现癌细胞表面有过量的6 7L R存在。这和癌细胞入侵和转移直接相关。因而 6 7L R在癌细胞穿透基层膜而转移的过程中起重要的作用。许多动物试验和流行病学的研究都显示茶叶具有抗多种类型癌症的功效 ,尤其是表没食子儿茶素没食子酸脂(EGCG)。但茶的抗癌机理并不完全清楚。不久前日本科学家 Tachlbana等人的研究找到了与 EGCG结合的受体 ,它就是与癌细胞入侵和转移起重要作用的 6 7L R。和用清水处理比较 ,有 6 7L R的人类肺癌细胞经 ECCG处理后其生长受到明显的抑制 ,浓度分别为 0 .1和 1
Tumors are cells that proliferate uninhibitedly. Malignancies can invade the surrounding cells, especially aggressive malignant cells. They penetrate and diffuse to the basement membrane (Basem ent mem brane) Go inside the organ. Basement membrane is a special differentiated extracellular matrix, normal cells can not penetrate this basement membrane. Laminin is a macromolecule glycoprotein that is widely distributed in the extracellular matrix. Through the cell surface receptors have the ability to communicate with the cells. They are the main attachment matrix for invading cancer cells. Direct adhesion of malignant cancer cells to lam inin is directly related to the potential metastatic potential of cancer cells. The study found that lam inin adhered to the surface of cancer cells with high affinity and can be saturated, suggesting the presence of laminin receptors. Later, it was found that a 6 7k D laminin receptor (67LR) and laminin have high affinity. Numerous studies have found that there is an excess of 6 7L R on the surface of cancer cells. This is directly related to cancer cell invasion and metastasis. Thus, 6 7L R plays an important role in the metastasis of cancer cells through the basilar membrane. Many animal experiments and epidemiological studies have shown that tea has efficacy against various types of cancer, especially epigallocatechin gallate (EGCG). However, the anticancer mechanism of tea is not fully understood. Not long ago, a study by Japanese scientist Tachlbana et al. Found a receptor that binds to EGCG, which is a 6 7L R that plays an important role in cancer cell invasion and metastasis. Compared with water treatment, 6 7L R human lung cancer cells were significantly inhibited by ECCG treatment at concentrations of 0.1 and 1