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自穆坪马兜铃(Aristolochia moupinensis Franch)根、茎中分得十三个化合物,其中化合物Ⅰ～Ⅻ经鉴定分別为马兜铃酸Ⅰ(aristolochic acid Ⅰ)(Ⅰ),尿囊素(allantoin)(Ⅱ),紫丁香酸(syringic acid)(Ⅲ),香豆酸(P-coumaric acid)(Ⅳ),马兜铃酸Ⅳ(aristolochic acid Ⅳ)(Ⅴ),β-谷甾醇(Ⅵ),木兰碱(magnoflorine)(Ⅶ),马兜铃酸Ⅳ甲醚aristolochic acid Ⅳ methyl ether(Ⅵ),棕榈酸(Ⅸ),马兜铃酸Ⅱ(aristolochic acid Ⅱ)(Ⅹ),N(Phydroxyphenethy1)P-coumaramide(Ⅺ),马兜铃酸Ⅳ甲醚甲酯(aristolochic acid Ⅳ methyl ether methyl ester)(Ⅻ),化合物ⅩⅢ为新化合物,经光谱分析和化学合成等方法证明其结构为N(P-hydroxyphenethyl)-ferulamide,命名为穆坪马兜铃酰胺(moupinamide)。 初步药理试验表明穆坪马兜铃酰胺体外有抑制血小板聚集和影响血小板内前列腺素合成的作用。
Thirteen compounds were isolated from the roots and stems of Aristolochia moupinensis Franch. Compounds I-XII were identified as aristolochic acid I (I) and allantoin (allantoin). (II), syringic acid (III), coumaric acid (IV), aristolochic acid IV (V), β-sitosterol (VI) , magnoflorine (VII), aristolochic acid IV methyl ether (VI), palmitic acid (IX), aristolochic acid II (X), N (Phydroxyphenethy1) P-coumaramide (XI), aristolochic acid IV methyl ether methyl ester (XII), compound XIII is a new compound and its structure is confirmed by spectral analysis and chemical synthesis. -hydroxyphenethyl)-ferulamide, named Moupin moupinamide. Preliminary pharmacological tests have shown that apolamine apatin inhibits platelet aggregation in vitro and influences platelet prostaglandin synthesis.