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白细胞介素-13(IL-13)是由活化T细胞分泌产生的一种细胞因子,它能抑制单核细胞释放炎性细胞因子和化学因子,诱导B细胞增殖和分化,促进IgE合成,引起变态反应,促进肺的纤维化,IL-13还参与造血调控,对原始造血前体细胞增殖和分化起一定作用,对巨核细胞生长有促进作用;骨髓增生异常综合征(MDS)是一组源于骨髓造血干/祖细胞的恶性克隆增殖性疾病,目前研究认为MDS的发病机制复杂,涉及凋亡、增殖以及免疫低监视性,IL-13在其发生发展中可能起到一定作用。
Interleukin-13 (IL-13) is a cytokine secreted by activated T cells that inhibits the release of inflammatory cytokines and chemokines by monocytes, induces B cell proliferation and differentiation, promotes IgE synthesis, and causes Allergy, promote lung fibrosis, IL-13 is also involved in hematopoietic regulation of primitive hematopoietic progenitor cells play a role in proliferation and differentiation, promote the growth of megakaryocytes; myelodysplastic syndrome (MDS) is a group of sources Currently, studies suggest that the pathogenesis of MDS is complex and involves apoptosis, proliferation and immunosurveillance, and IL-13 may play a role in the development of malignant clonal proliferative diseases of hematopoietic stem / progenitor cells.