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本文报告5例尿崩症患者。例1为特发性尿崩症患者,接受鞣酸血管加压素油剂(5 U)治疗20年,近来药物的疗效由维持2～3天变为4～6小时。检出血管加压素抗体效价为1∶160,因而改用氯磺丙脲(chlorpropamide)125 mg/日以控制病人的多尿,疗效甚好。停用加压素3年后复测血清加压素抗体效价降低至<1∶10。例2为颅咽管瘤合并尿崩症,于肿瘤切除后2年内,每2～3天注射鞣酸血管加压素油剂1次,同时应用可的松,甲状腺素片和睾酮控制其尿量。检测血清加压素抗体效价为1∶40,改用氯磺丙脲500mg/日治疗,3年后复测血清加压素抗体效价<1∶10。
This article reports 5 cases of diabetes insipidus patients. Example 1 In patients with idiopathic diabetes insipidus who received tannic acid vasopressin (5 U) for 20 years, the efficacy of the drug has recently changed from 2 to 3 days to 4 to 6 hours. The vasopressin antibody titer was detected at 1: 160, and thus chlorpropamide (chlorpropamide) was switched to 125 mg / day to control the polyuria in patients with excellent efficacy. Three years after the withdrawal of vasopressin serum vasopressin antibody titer reduced to <1:10. Case 2 is craniopharyngioma with diabetes insipidus, within 2 years after tumor resection, injection of tannin vasopressor oil every 2 to 3 days, while the application of cortisone, thyroxine tablets and testosterone control their urine output . Serum vasopressin antibody titers 1:40, switch to chlorpropamide 500mg / day treatment, 3 years after the test serum vasopressin antibody titer <1:10.