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速发型变态反应是IgE抗体与特异性抗原在肥大细胞和嗜碱性粒细胞膜上相互作用,使细胞释放炎性介质所引起的结果.本文主要介绍在速发型变态反应中,炎性介质白细胞三烯和IgE介导后期时相两个进展.IgE主要在呼吸道和胃肠道淋巴组织内合成,扁桃体和增殖腺中尤为丰富,(正常成年人血清IgE水平约为25mg/dl,胎儿可以合成IgE,但新生儿血清水平很低为0.23～0.46mg/dl,儿童期渐渐增长.)IgE之所以能结合于嗜碱性粒细胞和肥大细胞表面,是因两种细胞膜上均有IgE受体.IgE受体与IgE有高度亲和力,IgE被动转移后,皮肤致敏可继续存在几周.IgE与其受体的结合力很高,甚至有大量其它类型免疫球蛋白存在时亦不受影响.
Fast-haired allergic reaction is IgE antibody and specific antigen in the mast cells and basophil membrane interaction, so that cells release inflammatory mediators caused by the results of this article mainly in the rapid onset of allergic reactions, inflammatory mediators leukocyte three Ethylene and IgE mediate two late phases: IgE is mainly synthesized in the respiratory and gastrointestinal lymphoid tissues, and is particularly abundant in the amygdala and proliferating glands (serum IgE levels of approximately 25 mg / dl in normal adults and the fetus can synthesize IgE , But neonates have very low serum levels of 0.23 to 0.46 mg / dl and progressively increased in childhood.) IgE binds to the surface of basophils and mast cells because of IgE receptors on both cell membranes. IgE receptors and IgE have a high affinity, IgE passive transfer, skin sensitization can continue to exist for a few weeks.IgE binding to its receptor is high, and even a large number of other types of immune globulin in the presence of unaffected.