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目的观察大剂量纳洛酮联合奥扎格雷治疗急性脑梗死的临床效果。方法选取医院2013年1月-2014年12月收治的急性脑梗死患者210例,随机分为观察组和对照组各105例。2组均根据病情予以降血糖、调血压、控制颅内压等对症治疗。在此基础上,观察组给予大剂量纳洛酮联合奥扎格雷治疗;对照组给予常规剂量纳洛酮联合奥扎格雷治疗。观察2组患者的临床疗效及不良反应发生情况,评价2组患者在治疗前后的病损程度及致残率。结果治疗后观察组的总有效率91.4%为高于对照组的81.0%,差异有统计学意义(P<0.05)。治疗过程中2组均未出现严重不良反应。治疗后2组神经功能缺损评分均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。结论大剂量纳洛酮联合奥扎格雷治疗急性脑梗死可提高临床疗效,改善患者病情,值得临床推广应用。
Objective To observe the clinical effect of high-dose naloxone combined with ozagrel on acute cerebral infarction. Methods A total of 210 acute cerebral infarction patients admitted from January 2013 to December 2014 in our hospital were randomly divided into observation group (105 cases) and control group (105 cases). 2 groups were based on the disease to be hypoglycemic, adjusting blood pressure, control of intracranial pressure and other symptomatic treatment. On this basis, the observation group given high-dose naloxone combined with ozagrel treatment; control group given conventional dose of naloxone combined with ozagrel treatment. The clinical efficacy and adverse reactions of the two groups were observed and the degree of morbidity and disability of the two groups were evaluated before and after treatment. Results After treatment, the total effective rate in observation group was 91.4%, which was higher than that in control group (81.0%), the difference was statistically significant (P <0.05). No significant adverse reactions occurred in both groups during the course of treatment. After treatment, the scores of neurological deficit in both groups were lower than before treatment, and the observation group were lower than the control group, the difference was statistically significant (P <0.05). Conclusion High-dose naloxone combined with ozagrel in the treatment of acute cerebral infarction can improve the clinical curative effect and improve the patient’s condition, which is worthy of clinical application.