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IgM肾病是一个新的临床病理学名称。早在1978年,Cohen等人就描述了此病。其特征是系膜区弥漫性IgM沉积,电镜下有不同程度的电子致密物沉积。临床上主要表现为肾病综合征或蛋白尿,很少出现血尿,部分病人发生肾功能减退和肾衰竭,疗效不一。为此,作者对1978～1984年间的273例肾穿刺活检病例进行了总结,其中弥漫性系膜区IgM沉积者10例(3.6%),作者对这10例进行了病史复习及肾功能随访。结果:免疫荧光中IgM显不同程度的弥漫性颗粒状沉积,这些颗粒主要局限在系膜区,很少见于其它部分,有6例同时见C_3及其它Ig,但强度小于IgM。光镜下有些类似微小病变型,有些表现为不同程度弥漫性系膜细胞增生或伴球丛细胞数增多,5例见系膜基质增宽,部分有细胞增多,1例的非髓旁肾单位有
IgM nephropathy is a new clinical pathology name. As early as 1978, Cohen et al described the disease. It is characterized by diffuse IgM deposition in the mesangial area and deposition of electron-dense deposits under electron microscopy. The main clinical manifestations of nephrotic syndrome or proteinuria, hematuria rarely occurs, some patients with renal dysfunction and renal failure, with different effects. To this end, the authors reviewed 273 cases of renal biopsy between 1978 and 1984, of whom 10 (3.6%) had diffuse mesangial IgM deposits. The authors reviewed these 10 patients for history and follow-up of renal function. Results: Immunofluorescence showed diffuse granular deposition of IgM in varying degrees. These particles were confined mainly in the mesangial area and seldom seen in other parts. Six of them were found to be C_3 and other Ig, but their intensity was lower than that of IgM. Some similar micro-lesions of light lesions, and some showed varying degrees of diffuse mesangial cell proliferation or increased with the number of basal cells, 5 cases of widened mesangial matrix, some of the cells increased, and 1 case of non-medullary nephron units Have