Effect of Methyl-CpG Binding Domain Protein 2 （MBD2） on AMD-like Lesions in ApoE-Deficient Mice

• 作 者: 潘俊如 王琛 余其林 张述 李斌 胡军
• 机 构: DepartmentofOphthalmology,TheCenterforBiomedicalResearch
• 出 处: 华中科技大学学报：医学英德文版
• 发表日期: 2014年3期
• 关键词: 载脂蛋白E 小鼠模型 APOE 基因缺陷 AMD 结构域 CPG 甲基化 methyl-CpG binding domain protein 2 aged-r
• 基金项目: This study was supported by grants from Natural Science Foundation of Hubei Province （No： 2012FFB02304） and Scientific Research Foundation of Ministry of Education （No： 2013-1792）, China.

The role of methyl-CpG binding domain protein 2(MBD2) in an ApoE-deficient mouse model of age-related macular degeneration(AMD) was investigated. Eight-week-old Mbd2/ApoE double deficient(Mbd2-/- ApoE-/-) mice(n=12, 24 eyes, experimental group) and MBD2(w