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为进一步验证m p.s对HBeAg阴转的疗效,本试验采用双盲配对方法治疗40例慢乙肝,临床分三组进行观察。第一组为m.p.s+乙肝疫苗联合治疗组20例,第二组为单纯m.p.s组,第三组为安慰剂组,对第二、三组药品统一编号,采用双盲配对法共20例。各组疗程均为四个月。观察结果表明:m.p.s+乙肝疫苗联合组eAg阴转率为45％,单纯m.p.s组40％,安慰剂组20％,在HBV-DNA阴转方面,三组比较结果,第一组及第二组阴转率分别为66.6％及40％,而第三组别无一例阴转。提示m.p.s对乙肝病毒复制有一定的抑制作用。
In order to further verify the therapeutic effect of m p.s on HBeAg overcast, 40 patients with chronic hepatitis B were treated by double-blind pairing method in this study. The first group was m.p.s + hepatitis B vaccine combined treatment group of 20 cases, the second group was simple m.p.s group, the third group was placebo group, the second and third groups of drugs uniform number, double-blind matching method in 20 cases. Each treatment group were four months. The observation results showed that the eAg negative conversion rate was 45% in mps plus hepatitis B vaccine group, 40% in simple mps group and 20% in placebo group. In terms of HBV-DNA negative conversion, the results of the three groups, the first group and the second group Negative conversion rates were 66.6% and 40% respectively, while none in the third group was negative. Tip m.p.s on hepatitis B virus replication has a certain inhibitory effect.