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应用卵白素-生物素复合物(ABC)法技术和抗GST同族酶抗体对GST同族酶在口腔癌前病变及恶性病损中进行定位,同时以正常的口腔粘膜作对照观察,目的是研究GST-P作为口腔肿瘤标志的可能性, 有助于癌肿的早期诊断。 研究对象为正常的口腔粘膜组织9例,良性纤维增生者9例,有恶变倾向的白斑25例,粘膜下纤维变性12例,疣状增生16例。恶性病损,其中疣状癌13例。鳞状细胞癌高分化者26例,中到低分化者10例。标本经10％福尔马林固定和石蜡包埋,切片经苏木精
The GST family of enzymes were located in oral precancerous lesions and malignant lesions using the avidin-biotin complex (ABC) method and anti-GST family of antibody against the same family of oral mucosa as controls for the purpose of studying GST P as a possibility of oral tumor markers, contribute to the early diagnosis of cancer. The subjects were normal oral mucosa in 9 cases, benign fibrous hyperplasia in 9 cases, malignant white spot in 25 cases, submucosal fibrosis in 12 cases, 16 cases of verrucous hyperplasia. Malignant lesions, including verrucous carcinoma in 13 cases. 26 cases of squamous cell carcinoma with high differentiation, 10 cases of moderate to poor differentiation. Specimens were fixed with 10% formalin and paraffin embedded and sectioned with hematoxylin