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目的:分析并研究难治性抑郁症采取文拉法辛协同认知心理治疗的临床效果.方法:以2019年3月至2021年1月为研究区段,以该区段本科室收入的难治性抑郁症患者为探究主体,总计62例,运用随机数字表法分组,分为2组,1组为对照组(n=31),1组为试验组(n=31),接受单一文拉法辛诊疗者纳入对照组,基于此基础,接受认知心理治疗者纳入试验组,比较两组效果,如HAMD评分、有效率及不良反应等.结果:1)HAMD:试验组诊疗后2周、1个月、2个月HAMD相比于对照组明显较低(P＜0.05);2)有效率:试验组96.77％高于对照组74.19％(P＜0.05);3)不良反应:试验组口干、头晕等发生率与对照组比无较大差异(P＞0.05);4)复发率:随访半年,试验组复发率较对照组低(P＜0.05).结论:难治性抑郁症采取文拉法辛协同认知心理诊疗效果确切,可有效减轻抑郁情绪,降低复发率,且不良反应少,具较高的临床运用价值.“,”Objective: to analyze and study the clinical effect of venlafaxine combined with cognitive psychotherapy on refractory depression. Methods: from March 2019 to January 2021, 62 patients with refractory depression were randomly divided into two groups: control group (n = 31) and experimental group (n = 31), The patients who received cognitive psychotherapy were included in the experimental group, and the effects, such as HAMD score, effective rate and adverse reactions, were compared between the two groups. Results: 1) HAMD: compared with the control group, the experimental group had significantly lower HAMD at 2 weeks, 1 month and 2 months after diagnosis and treatment (P ＜ 0.05); 2) Effective rate: 96.77％ in the experimental group was higher than 74.19％ in the control group (P ＜ 0.05); 3) Adverse reactions: there was no significant difference in the incidence of dry mouth and dizziness between the experimental group and the control group (P ＞ 0.05); 4) Recurrence rate: follow up for half a year, the recurrence rate of the experimental group was lower than that of the control group (P ＜ 0.05). Conclusion: the effect of venlafaxine combined with cognitive psychology in the treatment of refractory depression is exact, which can effectively reduce the depression, reduce the recurrence rate, and has less adverse reactions.