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目的探讨原因不明性复发流产(URSA)患者主动免疫治疗后CD细胞封闭效率变化及再次妊娠后对其进行加强免疫治疗的效果。方法对URSA患者应用外周血淋巴细胞进行主动免疫治疗,检测治疗前后患者外周血抗配偶CD3+、CD4+、CD8+细胞封闭效率。同时观察不同次数的加强免疫治疗后患者再次妊娠结局。结果对URSA患者进行免疫治疗可提高抗配偶CD3+、CD4+、CD8+细胞封闭效率。对妊娠后患者加强免疫治疗总次数及再次妊娠成功率比较发现:妊娠后加强免疫治疗3次的患者,效果最好。结论对URSA患者进行免疫治疗可提高抗配偶CD细胞封闭效率,URSA患者再次妊娠后应继续加强免疫治疗3次,可以显著的降低再次流产的发生,达到满意的疗效。
Objective To investigate the effect of active immunotherapy on patients with recurrent unexplained recurrent spontaneous abortion (URSA), and to study the effect of active immunotherapy on the closure efficiency of CD cells and the intensive immunotherapy after pregnancy again. Methods URSA patients were immunized with peripheral blood lymphocytes to detect the anti-spouse anti-spouse CD3 +, CD4 +, CD8 + cell sealing efficiency in patients before and after treatment. At the same time observe the different number of intensive immunotherapy patients again after the pregnancy outcome. Results Immunotherapy of URSA patients could increase the blocking efficiency of anti-spouse CD3 +, CD4 + and CD8 + cells. The total number of patients after intensive immunotherapy in pregnancy and the success rate of pregnancy again found that: three times after immunostimulatory therapy in patients with the best results. Conclusion The immunotherapy of URSA patients can improve the anti-spouse CD cell blocking efficiency. URSA patients should continue to strengthen the immune therapy three times after pregnancy again, which can significantly reduce the occurrence of recurrent miscarriage and achieve satisfactory curative effect.