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目的探讨系统性红斑狼疮合并深部真菌感染的病原学特征和易感因素。方法回顾性分析62例系统性红斑狼疮合并深部真菌感染患者的临床资料。结果肺部感染最常见占51.6%,其次为口腔感染占19.4%,胃肠道占9.7%等;酵母菌属中以白色念珠菌为主,占51.6%,其次是新生隐球菌(14.5%)和光滑念珠菌(9.7%)。病程、激素使用时间、免疫抑制剂及抗生素、低蛋白血症是深部真菌感染的易感因素。结论病程超过3年、激素使用超过1年、联合免疫抑制剂、广谱抗生素超过2周、低蛋白血症为系统性红斑狼疮深部真菌感染易感因素,早期预防并治疗可有效降低系统性红斑狼疮患者真菌感染发生率及死亡率。
Objective To explore the etiological characteristics and susceptibility factors of systemic lupus erythematosus complicated with deep fungal infection. Methods The clinical data of 62 patients with systemic lupus erythematosus complicated with deep fungal infection were retrospectively analyzed. Results The most common infection was lung infection (51.6%), followed by oral infection (19.4%) and gastrointestinal tract (9.7%). Candida albicans was the dominant species in yeast (51.6%), followed by Cryptococcus neoformans (14.5% And Candida glabrata (9.7%). Course of disease, hormone use time, immunosuppressive agents and antibiotics, hypoproteinemia is a susceptible factor for deep fungal infections. Conclusions Duration of more than 3 years, hormones used for more than 1 year, combined with immunosuppressive agents, broad-spectrum antibiotics for more than 2 weeks, hypoproteinemia is a susceptible factor for systemic fungal infection of deep fungal infection, early prevention and treatment can effectively reduce systemic erythema Fungal infection and mortality in patients with lupus.