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目的:筛选制备头孢呋辛酯分散片的合适处方,确保其溶出度符合中国药典(2005版)的相关规定。方法:采用单因素设计方法,以体外累积溶出度测定作为评价指标,研究崩解剂的差异对其累积溶出度的影响。结果:两个处方分别在15min和45min两点处的累积溶出度有显著性差异(p<0.01),分别为58.8%、84.7%和82.2%、98.2%。结论:崩解剂的厂家及规格的不同,对头孢呋辛酯的溶出有显著性影响。
Objective: To screen suitable preparation of cefuroxime axetil dispersible tablet to ensure its dissolution in line with the relevant provisions of the Chinese Pharmacopoeia (2005 edition). Methods: The single factor design method was used to evaluate the cumulative dissolution rate of disintegration agent in vitro. Results: The cumulative dissolution rates of two prescriptions at 15min and 45min respectively were significantly different (p <0.01), which were 58.8%, 84.7% and 82.2%, 98.2% respectively. Conclusion: The disintegration of the manufacturers and specifications of the cefuroxime axetil dissolution have a significant impact.