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1 临床资料 患者,男22岁,因齿龈肿痛、出血伴低热2周,于1989年1月31日入院。血红蛋白120g/L,血小板21×10~9/L,白细胞10.5×10~9/L,分类:原粒0.21,原+幼单0.61。骨髓增生极度活跃,原+早幼粒0.27原+幼单0.52,嗜酸粒0.08,未见尼曼-匹克细胞,诊断为急性粒—单细胞性白血病。予HOAP、HP方案治疗后,3月25日骨髓完全缓解,但全片(2.5 cm×3cm)见尼曼-匹克细胞8个,并接受巩固强化治疗,2疗程后,于1989年6月4日出院。1989年8月18日再次入院强化治疗时,除白细胞偏低(1.6×10~9/L)外,血
1 Clinical data Patients, male, 22 years old, due to gingival swelling and pain, bleeding with fever for 2 weeks, was January 31, 1989 admission. Hemoglobin 120g / L, platelets 21 × 10 ~ 9 / L, white blood cells 10.5 × 10 ~ 9 / L, classification: Myeloid hyperplasia is extremely active, the original pro-promyelocytic 0.27 original + young single 0.52, eosinophilic 0.08, no Niemann-Pick cells, the diagnosis of acute granulocytic leukemia. After treatment with HOAP and HP, the bone marrow was completely relieved on March 25, but the whole piece (2.5 cm × 3 cm) was seeded with 8 Niemann-Pick cells and underwent consolidation and intensive treatment. After 2 courses of treatment, on June 4, 1989 Sunrise home. August 18, 1989 re-admission intensive treatment, in addition to low white blood cells (1.6 × 10 ~ 9 / L), the blood