论文部分内容阅读
肿瘤转移是决定肿瘤病人预后的关键因素,也是恶性肿瘤病人的主要死因,如何阻断肿瘤的浸润转移是治愈肿瘤的关键环节.肿瘤转移是一个多步骤复杂过程,肿瘤细胞必须先脱离原发部位,侵入细胞外基质(ECM),与基底膜(BM)及ECM中一些大分子细胞蛋白成分粘附,并激活细胞合成分泌各种降解酶类,穿透血管壁进入循环系统,再穿透血管外渗到继发部位,与继发部位组织粘附形成克隆,增殖生长而形成转移灶.肿瘤细胞浸润转移与内皮细胞关系较密切.癌细胞产生的胶原酶和肿瘤生长因子(TGF)等能直接或间接引起内皮细胞活化,产生胶原酶原及血小板活化因子(PAF)使癌细胞在血管内形成肿瘤血栓.进而癌细胞产生蛋白分解酶,破坏细胞外基质和血管内皮细胞组成的基底膜,导致癌细胞的浸润及转移.肿瘤血行转移的关键步骤之一是血液中的癌细胞栓子附着在血管内皮上,血小板释放凝集素,使肿瘤细胞与内皮细胞粘附,血管内皮细胞收缩变圆,
Tumor metastasis is a key factor in determining the prognosis of patients with cancer, and is also the main cause of death in patients with malignant tumors. How to block the invasion and metastasis of tumors is the key to curing tumors. Tumor metastasis is a multi-step complex process, and tumor cells must first break away from the primary site. , invades the extracellular matrix (ECM), adheres to some macromolecular cellular protein components in the basement membrane (BM) and ECM, and activates the cells to synthesize and secrete various degradative enzymes, penetrates the blood vessel wall into the circulatory system, and then penetrates blood vessels. Extravasation to the secondary site, adhesion with the secondary site of the formation of clones, proliferation and growth to form metastases. Tumor cell infiltration and metastasis and endothelial cells are more closely related to cancer cells produce collagenase and tumor growth factor (TGF) and other energy Directly or indirectly causes activation of endothelial cells, producing collagenase and platelet-activating factor (PAF), which causes cancer cells to form tumor thrombi in blood vessels. In turn, cancer cells produce proteolytic enzymes that destroy the basement membrane composed of extracellular matrix and vascular endothelial cells. Causes infiltration and metastasis of cancer cells. One of the key steps in metastasis of tumor blood is the adhesion of cancer cell emboli in the blood to the vascular endothelium. Release lectins, tumor cell adhesion to endothelial cells, endothelial cell shrinkage and round,