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目的探讨粪便Hp抗原检测方法在诊断儿童Hp感染中的价值。方法用ELISA试剂盒对100例有上消化道症状患儿的粪便标本进行Hp抗原检测,同时进行胃粘膜活检标本快速尿素酶试验、组织学染色和血清学试验,3项检查中至少2项阳性作为“金标准”判定为Hp感染。结果“金标准”诊断Hp感染阳性36例,阴性64例,阳性的36例中34例粪便抗原检测阳性,阴性的64例中60例粪便抗原检测阴性。敏感度94.4%,特异度93.8%,准确度94.0%。结论粪便Hp抗原检测简便易行、无创伤性、经济、准确性高,值得推广。
Objective To investigate the value of stool Hp antigen detection in the diagnosis of Hp infection in children. Methods Hp antigen was detected in 100 cases of stool samples from children with upper gastrointestinal symptoms by ELISA kit. Meanwhile, rapid urease test, histological staining and serological tests were performed on gastric biopsy specimens. At least two of the three tests were positive As a “gold standard” for the Hp infection. Results The gold standard diagnosis of positive Hp infection in 36 cases, negative in 64 cases, positive in 36 cases of 34 cases stool antigen test positive, negative in 64 cases of 60 cases of fecal antigen negative. Sensitivity 94.4%, specificity 93.8%, accuracy 94.0%. Conclusion The detection of stool Hp antigen is simple and easy to operate, noninvasive, economical and accurate. It is worth to be popularized.