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目的:探讨慢性充血性心力衰竭(CHF)患者血浆N-末端脑钠肽前体(NT-proBNP)浓度及血清尿酸(UA)浓度变化及其相关性。方法:65例心功能不全患者,按左室射血分数(LVEF)分两组,即LVEF>40%组(32例),LVEF≤40%组(33例);30例健康体检者作为正常对照组。所有入选者入院后常规检查NT-proBNP,UA,超声心动图测定LVEF。结果:LVEF≤40%组NT-proBNP[1102.3(276.34,1483.3)pg/ml]和UA[478.0(351.5,576.7)μmol/L]水平较LVEF>40%组[91.5(22.07,165.6)pg/ml;344.7(264.6,424.6)μmol/L]和正常对照组[14.6(5.4,54.1)pg/ml;289.7(214.6,326.3)μmol/L]显著升高,P均<0.01;LVEF>40%组NT-proBNP水平显著高于正常对照组(P<0.01),UA水平差异无显著性(P>0.05);心功能不全患者NT-proBNP与UA呈正相关(r为0.46,P<0.01);LVEF与NT-proBNP和UA均呈负相关(r=-0.63、-0.42,P均<0.01)。结论:慢性充血性心力衰竭患者血NT-proBNP浓度和UA浓度升高,且两者呈正相关。测定NT-proBNP和UA浓度有助于判断病情,早期治疗,改善预后。
Objective: To investigate the changes of plasma N-terminal pro brain natriuretic peptide (NT-proBNP) and serum uric acid (UA) in patients with chronic congestive heart failure (CHF) and their correlation. Methods: Sixty-five patients with cardiac insufficiency were divided into two groups according to left ventricular ejection fraction (LVEF): LVEF> 40% (32 cases) and LVEF≤40% (33 cases), and 30 healthy subjects as normal Control group. All candidates were routinely examined for NT-proBNP, UA, and echocardiography for LVEF after admission. Results: The levels of NT-proBNP [1102.3 (276.34,1483.3) pg / ml] and UA [478.0 (351.5,576.7) μmol / L] in LVEF≤40% group were significantly higher than those in LVEF> 40% group [91.5 (22.07,165.6) pg / ml; 344.7 (264.6,424.6) μmol / L] and normal control group [14.6 (5.4,54.1) pg / ml and 289.7 (214.6,326.3) μmol / L] The level of NT-proBNP was significantly higher than that of the normal control group (P <0.01), while the level of UA was not significantly different (P> 0.05). NT-proBNP was positively correlated with UA in patients with cardiac insufficiency (r = 0.46, P <0.01) LVEF was negatively correlated with NT-proBNP and UA (r = -0.63, -0.42, P <0.01). Conclusion: The blood levels of NT-proBNP and UA in patients with chronic congestive heart failure are increased, and the two are positively correlated. Determination of NT-proBNP and UA concentrations help to determine the condition, early treatment, improve prognosis.