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目的研究宫颈电环切除术(LEEP)后用药对创面愈合和不良反应的影响,寻找可加速创面愈合、减少不良反应的药物。方法 240例因宫颈上皮内瘤变(CIN)行LEEP的患者,随机等分为三组(每组80人):口服药组、聚甲酚磺醛栓组、纳米银栓组。分析三组术后创面愈合时间、不良反应发生率。结果治愈率95.4%,复发率2.5%,感染率2.9%,宫颈子宫内膜异位症发生率6.7%,宫颈腺上皮增生发生率7.1%。聚甲酚磺醛栓组的术后阴道排液时间、出血时间,宫颈子宫内膜异位症、宫颈腺上皮增生发生率均低于纳米银栓组及口服药组(P<0.05),差异有显著性意义,纳米银栓组及口服药组无差异;三组复发率、感染率无差异。聚甲酚磺醛栓组比纳米银栓组及口服药组创面愈合快(P<0.05),纳米银栓组及口服药组无差异。结论甲酚磺醛栓能促进CIN患者LEEP后创面愈合,有效减少术后不良反应,使用方便,病人依从性好。
Objective To study the effects of medication on wound healing and adverse reactions after LEEP, in order to find the drugs that can accelerate wound healing and reduce adverse reactions. Methods A total of 240 patients with LEEP due to cervical intraepithelial neoplasia (CIN) were randomly divided into three groups (80 in each group): oral drug group, polycresol sulfone suppository group and nano silver suppository group. Three groups of wound healing time, the incidence of adverse reactions were analyzed. Results The cure rate was 95.4%, the recurrence rate was 2.5%, the infection rate was 2.9%, the incidence of cervical endometriosis was 6.7%, and the incidence of cervical glandular epithelial hyperplasia was 7.1%. The incidences of postoperative vaginal discharge, bleeding time, cervical endometriosis and cervical glandular epithelial hyperplasia were lower in the group receiving polycresol sulfone suppository than those in the group receiving nano-silver suppository and oral administration (P <0.05) There was no significant difference between Nano silver suppository group and oral drug group. The recurrence rate and infection rate of the three groups showed no difference. Psoriasin sulfone suppository group was faster than the nano-silver suppository group and oral drug group wound healing (P <0.05), nano silver suppository group and oral drug group no difference. Conclusion cresol sulphide suppository can promote the wound healing of LEEP after CIN, effectively reduce the postoperative adverse reactions, easy to use and patient compliance.