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目的探讨氟哌噻吨美利曲辛片联合缬沙坦治疗高血压并焦虑症患者的临床疗效。方法选取崇明县三星镇社区卫生服务中心门诊2014—2015年收治的高血压并焦虑症患者100例,随机分为对照组和观察组,各50例。对照组患者给予缬沙坦治疗,观察组患者在对照组基础上给予氟哌噻吨美利曲辛片治疗。比较两组患者的血压控制效果,治疗前后汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)及不良反应发生情况。结果治疗后,观察组患者血压控制效果优于对照组(P<0.05)。治疗前,两组患者HAMA、HAMD评分比较,差异无统计学意义(P>0.05);治疗后,观察组患者HAMA、HAMD评分低于对照组(P<0.05)。两组患者治疗期间均未见明显不良反应发生。结论氟哌噻吨美利曲辛片联合缬沙坦治疗高血压并焦虑症患者临床疗效确切,可有效缓解患者焦虑、抑郁症状,且安全性好。
Objective To investigate the clinical efficacy of flupenthixol and melitracen in combination with valsartan in the treatment of patients with hypertension and anxiety. Methods One hundred patients with hypertension and anxiety disorder admitted to outpatient department of Sanxing Community Health Service Center in Chongming County from 2014 to 2015 were randomly divided into control group and observation group, with 50 cases in each group. Patients in the control group were given valsartan. Patients in the observation group were given flupentixol and melitracen tablets on the basis of the control group. The effect of blood pressure control, Hamilton Anxiety Scale (HAMA) score, Hamilton Depression Rating Scale (HAMD) and adverse reactions before and after treatment were compared between the two groups. Results After treatment, the blood pressure in the observation group was better than that in the control group (P <0.05). Before treatment, there was no significant difference in HAMA and HAMD scores between the two groups (P> 0.05). After treatment, HAMA and HAMD scores in the observation group were lower than those in the control group (P <0.05). No significant adverse reactions occurred in both groups during treatment. Conclusions Flupenthixol and melitracen tablets combined with valsartan in the treatment of patients with hypertension and anxiety have definite curative effect, which can relieve anxiety and depressive symptoms effectively and have good safety.