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多发性创伤常并发脓毒症,从而导致呼吸衰竭和成人呼吸窘迫综合征的发生。为了比较类固醇(甲强龙)和NSAID(非类固醇性抗炎症药物,如布洛芬)对心血管、肺和血液学的生理影响,作者进行了一系列实验性研究。取公猪24头分成5组:(Ⅰ)药物对照,猪3头,给布洛芬12.5 mg/kg二次;(Ⅱ)药物对照,3头,给甲强龙20mg/kg二次;(Ⅲ)病猪对照组,6头,滴注100％致死量的绿脓杆菌;(Ⅳ)治疗组,6头,滴注绿脓杆菌,给予布洛芬治疗;(Ⅴ)治疗组,6头,滴注绿脓杆菌后给予甲强龙治疗。实验动物在乙酰丙嗪肌肉和戊巴比妥钠静脉
Multiple traumatic injuries often complicate sepsis, leading to respiratory failure and adult respiratory distress syndrome. In order to compare the cardiovascular, pulmonary and hematological effects of steroids (methylprednisolone) and NSAIDs (non-steroidal anti-inflammatory drugs such as ibuprofen), the authors conducted a series of experimental studies. The boars 24 were divided into 5 groups: (Ⅰ) drug control, 3 pigs, given ibuprofen 12.5 mg / kg twice; (Ⅱ) drug control, 3, to methylprednisolone 20mg / kg twice; (Ⅳ) treatment group, 6, drip Pseudomonas aeruginosa, given ibuprofen treatment; (Ⅴ) treatment group, 6 , Drip Pseudomonas aeruginosa after treatment given a strong dragon. Experimental animals in acepromazine muscle and pentobarbital sodium vein