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目的:探讨经鼻空肠管早期行肠内营养(EN)在重症急性胰腺炎(S AP)治疗中的作用。方法:40例SAP患者随机分为治疗组和对照组,每组各20例,对照组给予常规治疗,治疗组在常规治疗的基础上加用肠内营养。观察两组治疗前后血清白蛋白和淀粉酶水平、血浆内毒素及肿瘤坏死因子TNF-α水平的变化情况。考察治愈率症、感染率、病死率、平均住院时间及费用。结果:治疗组患者行肠内营养后,血浆内毒素、TNF-α下降速度明显快于对照组P<0.05,感染率、平均住院时间与费用明显降低。结论:EN能改善ASP患者的营养状况,改善肠道黏膜屏障及降低炎性细胞因子分泌来加强治疗效果,是SAP重要治疗手段。
Objective: To investigate the role of nasal jejunum early enteral nutrition (EN) in the treatment of severe acute pancreatitis (S AP). Methods: Forty patients with SAP were randomly divided into treatment group and control group, with 20 cases in each group. The control group was given routine treatment. The treatment group was given enteral nutrition on the basis of routine treatment. Serum albumin and amylase levels, plasma endotoxin and tumor necrosis factor-α (TNF-α) levels were observed before and after treatment. Investigate cure rate disease, infection rate, case fatality rate, average length of hospital stay and cost. Results: After treatment of enteral nutrition, the plasma endotoxin and TNF-αdecreased significantly faster in treatment group than in control group (P <0.05), and the infection rate, average length of stay and cost were significantly reduced. Conclusion: EN can improve the nutritional status of patients with ASP, improve the intestinal mucosal barrier and reduce the secretion of inflammatory cytokines to enhance the therapeutic effect, is an important SAP treatment.